High-performance liquid chromatographic analysis of dextromethorphan, guaifenesin and benzoate in a cough syrup for stability testing.

Isolation and Gas Chromatographic Analysis of Dextromethorphan from Cough Syrup

In the previous laboratory experiment, we saw how the intermolecular forces between molecules determined the boiling point of a liquid. Distillation was one method which could be used to separate (or purify) chemical compounds. Unfortunately, distillation is not always a practical method to employ for purifications. Large molecules can have extremely high boiling points, even under reduced pres...

Nora H. Al-Shaalan et al: Determination of Chlorphineramine maleate, Dextromethorphan HBR and Phenylephrin HCl in Codilar syrup using HPLC

A simple, selective, sensitive and precise, simultaneous high performance liquid chromatographic analysis of syrup containing Chlorphineramine Maleate, Dextromethorphan HBr and Phenylephrin HCl was described. Good chromatographic separation was achieved using a Zorbax C18 (4.6 cm x 250 mm, 5 μm) and a mobile phase consisting of acetonitrile-phosphate buffer pH 3.5 (15:85, v/v) at a flow rate 0....

Stability-indicating HPLC Method for Simultaneous Determination of Terbutaline Sulphate, Bromhexine Hydrochloride and Guaifenesin

The aim of the present study was the development and subsequent validation of a simple, precise and stability-indicating reversed phase HPLC method for the simultaneous determination of guaifenesin, terbutaline sulphate and bromhexine hydrochloride in the presence of their potential impurities in a single run. The photolytic as well as hydrolytic impurities were detected as 3,5-dihydroxybenzoic...

High performance liquid chromatographic analysis of sugars in raw and processed potatoes

Simultaneous Quantitation of Theophylline and Guaifenesin in Syrup by HPLC, Derivative and Derivative Ratio Spectrophotometry for Quality Control Purposes

The aim of the present work was to develop a simple and rapid method for determination of theophylline (THP) and guaifenesin (GU) in syrup without involving any preparation operations like separation or masking. A HPLC and two spectrophotometric methods based on the derivation of the main spectra are described for the determination of THP and GU in combined pharmaceutical syrup form. The first ...